Article
Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane.
Traffic (Copenhagen, Denmark) - 1 Nov 2006
Chen Sophie, Wang Jiyi, Muthusamy Baby-Periyanayaki, Liu Ke, Zare Sara, Andersen Raymond J, Graham Todd R
Abstract excerpt
Drs2p, a P-type adenosine triphosphatase required for a phosphatidylserine (PS) flippase activity in the yeast trans Golgi network (TGN), was first implicated in protein trafficking by a screen for mutations synthetically lethal with arf1 (swa). Here, we show that SWA4 is allelic to CDC50, encoding a membrane protein previously shown to chaperone Drs2p from the endoplasmic reticulum to the Golgi complex. We find...
Topics
- Amino Acid Sequence
- Annexin A5
- Calcium-Transporting ATPases
- Carboxypeptidases
- Cathepsin A
- Cell Membrane
- Clathrin Heavy Chains
- Cloning, Molecular
- Depsipeptides
- Endocytosis
- Endoplasmic Reticulum
- Glycosylation
- Golgi Apparatus