Article
Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo.
Current biology : CB - 17 Sept 2002
Gall Walter E, Geething Nathan C, Hua Zhaolin, Ingram Michael F, Liu Ke, Chen Sophie I, Graham Todd R
Abstract excerpt
The small GTP binding protein ARF has been implicated in budding clathrin-coated vesicles (CCVs) from Golgi and endosomal membranes. An arf1 synthetic lethal screen identified DRS2/SWA3 along with a clathrin heavy-chain conditional allele (chc1-5/swa5-1) and SWA2, encoding the yeast auxilin-like protein involved in uncoating CCVs. Drs2p/Swa3p is a P-type ATPase and a potential aminophospholipid translocase that...
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