Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histopathology of alpha 1-antitrypsin liver disease in a transgenic mouse model.

Hepatology (Baltimore, Md.) - 1 Jul 1990

Geller S A, Nichols W S, Dycaico M J, Felts K A, Sorge J A

Abstract excerpt

Transgenic mice were constructed using human alpha 1-antitrypsin M and Z genomic clones. Livers of the M lineage mice showed slight cellular pleomorphism and immunohistochemically demonstrable finely granular alpha 1-antitrypsin material in hepatocytes. Z lineage mice with five gene copies per haploid mouse genome (Z#1) demonstrated fine granular alpha 1-antitrypsin material and a few large globules. In contrast,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to alpha 1-Antitrypsin
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Reference Values

Source

Identifiers

PMID: 1695605
DOI: 10.1002/hep.1840120108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histopathology of alpha 1-antitrypsin liver disease in a transgenic mouse model.PMID 1695605Read ↗

Evaluation of a transgenic mouse model for alpha-1-antitrypsin (AAT) related liver disease.Semantic proximity Read ↗

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency.Semantic proximity Read ↗

Hepatic progenitor cell proliferation and liver injury in α-1-antitrypsin deficiency.Semantic proximity Read ↗

Alpha-1-antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model.Semantic proximity Read ↗

Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.Semantic proximity Read ↗

Transgenic hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Expression of hepatitis C virus envelope proteins in transgenic miceSemantic proximity Read ↗

Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.Semantic proximity Read ↗

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic miceSemantic proximity Read ↗

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice.Semantic proximity Read ↗

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.Semantic proximity Read ↗

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.