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Article

Histopathology of alpha 1-antitrypsin liver disease in a transgenic mouse model.

Hepatology (Baltimore, Md.) - 1 Jul 1990

Geller S A, Nichols W S, Dycaico M J, Felts K A, Sorge J A

Abstract excerpt

Transgenic mice were constructed using human alpha 1-antitrypsin M and Z genomic clones. Livers of the M lineage mice showed slight cellular pleomorphism and immunohistochemically demonstrable finely granular alpha 1-antitrypsin material in hepatocytes. Z lineage mice with five gene copies per haploid mouse genome (Z#1) demonstrated fine granular alpha 1-antitrypsin material and a few large globules. In contrast,...

Topics

Alleles
Animals
Enzyme-Linked Immunosorbent Assay
Humans
Liver
Liver Diseases
Mice
Mice, Transgenic
RNA
Reference Values
alpha 1-Antitrypsin

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Identifiers

PMID: 1695605
DOI: 10.1002/hep.1840120108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1695605-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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