Article
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.
Gastroenterology - 1 Feb 2002
Lerat Hervé, Honda Masao, Beard Michael R, Loesch Kim, Sun Jiaren, Yang Yan, Okuda Michiari, Gosert Rainer, Xiao Shu-Yuan, Weinman Steven A, Lemon Stanley M
Abstract excerpt
BACKGROUND & AIMS: The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS: Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structural proteins (S-N transgene) were compared with nontransgenic littermates for altered liver...
Topics
- Animals
- Apoptosis
- Cell Division
- Fatty Liver
- Female
- Gene Expression Regulation, Viral
- Hepacivirus
- Hepatitis C, Chronic
- Liver Cirrhosis
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H