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Article

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes.

The Journal of clinical investigation - 1 May 2011

Ding Jianqiang, Yannam Govardhana R, Roy-Chowdhury Namita, Hidvegi Tunda, Basma Hesham, Rennard Stephen I, Wong Ronald J, Avsar Yesim, Guha Chandan, Perlmutter David H, Fox Ira J, Roy-Chowdhury Jayanta

Abstract excerpt

α1-Antitrypsin deficiency is an inherited condition that causes liver disease and emphysema. The normal function of this protein, which is synthesized by the liver, is to inhibit neutrophil elastase, a protease that degrades connective tissue of the lung. In the classical form of the disease, inefficient secretion of a mutant α1-antitrypsin protein (AAT-Z) results in its accumulation within hepatocytes and...

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Identifiers

PMID: 21505264
DOI: 10.1172/JCI45260
PMCID: PMC3083768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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