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Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1 Dec 1990

Abstract excerpt

The hepatitis B virus X protein acts as a transcriptional transactivator in vitro. To elucidate possible biological effects of X protein on liver cells in vivo, we generated four lines of transgenic mice carrying the X gene open reading frame under the control of the human alpha-1-antitrypsin regulatory region. The plasmid construct used to introduce the transgene was shown to encode a 16-kDa X protein with...

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PMID: 2243380
DOI: 10.1128/jvi.64.12.5939-5947.1990

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