Article
Evaluation of a transgenic mouse model for alpha-1-antitrypsin (AAT) related liver disease.
Annals of human genetics - 1 Oct 1994
Ali R, Perfumo S, della Rocca C, Amicone L, Pozzi L, McCullagh P, Millward-Sadler H, Edwards Y, Povey S, Tripodi M
Abstract excerpt
We have attempted to produce a transgenic mouse model of the neonatal liver disease associated with the human PIZ allele. Analysis of a number of transgenic mouse lines carrying either a normal human PIM gene construct or the mutant Z is reported. Using isoelectric focusing analysis of plasma fro...
Topics
- Animals
- Animals, Newborn
- Blotting, Northern
- Disease Models, Animal
- Evaluation Studies as Topic
- Gene Expression
- Humans
- Immunoenzyme Techniques
- Liver
- Liver Diseases
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Mutation
- alpha 1-Antitrypsin