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Article

Evaluation of a transgenic mouse model for alpha-1-antitrypsin (AAT) related liver disease.

Annals of human genetics - 1 Oct 1994

Ali R, Perfumo S, della Rocca C, Amicone L, Pozzi L, McCullagh P, Millward-Sadler H, Edwards Y, Povey S, Tripodi M

Abstract excerpt

We have attempted to produce a transgenic mouse model of the neonatal liver disease associated with the human PIZ allele. Analysis of a number of transgenic mouse lines carrying either a normal human PIM gene construct or the mutant Z is reported. Using isoelectric focusing analysis of plasma from transgenic mice, we have shown that the human AAT proteins produced in mice are processed in a similar way to their...

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PMID: 7864587
DOI: 10.1111/j.1469-1809.1994.tb00728.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evaluation of a transgenic mouse model for alpha-1-antitrypsin (AAT) related liver disease.PMID 7864587Read ↗

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