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Article

Hepatic progenitor cell proliferation and liver injury in α-1-antitrypsin deficiency.

Journal of pediatric gastroenterology and nutrition - 1 Nov 2010

Brunt Elizabeth M, Blomenkamp Keith, Ahmed Muneeb, Ali Faiza, Marcus Nancy, Teckman Jeffrey

Abstract excerpt

OBJECTIVES: Homozygous ZZ α-1-antitrypsin (a1AT) deficiency is a common genetic liver disease that causes liver injury and hepatocellular carcinoma (HCC). The a1AT mutant Z gene encodes a mutant protein that accumulates within hepatocytes leading to hepatocellular death and a hepatic regenerative response. However, the mechanisms linking hepatocellular injury to these responses are poorly understood. In this...

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Identifiers

PMID: 20890217
DOI: 10.1097/MPG.0b013e3181e7ff55
PMCID: PMC2965205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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