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Article

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency.

Experimental biology and medicine (Maywood, N.J.) - 1 Oct 2012

Marcus Nancy Y, Blomenkamp Keith, Ahmad Muneeb, Teckman Jeffrey H

Abstract excerpt

Alpha-1-antitrypsin deficiency is a genetic disorder resulting in the expression of misfolded mutant protein that can polymerize and accumulate in hepatocytes, leading to liver disease in some individuals. Transgenic PiZ mice are a well-characterized model, which express human alpha-1-antitrypsin mutant Z protein (ATZ protein) and faithfully recapitulate the human liver disease. Liver tissue expressing...

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Source

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Identifiers

PMID: 23104507
DOI: 10.1258/ebm.2012.012106
PMCID: PMC3510980

Genes

CBR3
GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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