Article
Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population.
European heart journal - 1 Nov 2006
Koch Werner, Hoppmann Petra, Pfeufer Arne, Schömig Albert, Kastrati Adnan
Abstract excerpt
AIMS: The toll-like receptor 4 (TLR4) is predominantly known for its role as an important mediator of immune reactions and has been implicated in the initiation, progression, and plaque destabilization stages of atherosclerosis. We investigated whether genotypes and haplotypes of the 896A/G (Asp299Gly; rs4986790) and 1196C/T (Thr399Ile; rs4986791) single nucleotide polymorphisms of the gene encoding the TLR4 were...
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