Article
Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes.
American heart journal - 1 Dec 2004
Kolek Matthew J, Carlquist John F, Muhlestein Joseph B, Whiting Bryant M, Horne Benjamin D, Bair Tami L, Anderson Jeffrey L
Abstract excerpt
BACKGROUND: Coronary artery disease (CAD) and, increasingly, diabetes are recognized as having an inflammatory basis. Membrane toll-like receptors (TLRs) activate signaling pathways that up-regulate inflammation. We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.