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Article

Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction.

Pharmacogenetics and genomics - 1 Jan 2005

Holloway John W, Yang Ian A, Ye Shu

Abstract excerpt

Variation in the gene encoding toll-like receptor 4 (TLR4), a transmembrane receptor that mediates inflammatory responses to bacterial endotoxin, has been associated with susceptibility to atherosclerosis and its complications, such as myocardial infarction (MI), the pathogenesis of which involves inflammation. A recent study has also indicated that TLR4 gene variation influences the effect of statin treatment on...

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Source

Identifiers

PMID: 15864121
DOI: 10.1097/01213011-200501000-00003

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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