Article
Toll-like receptor 4 gene polymorphisms show no association with the risk of clinical or angiographic restenosis after percutaneous coronary intervention.
Pharmacogenetics and genomics - 1 Sept 2010
Beijk Marcel A M, Boekholdt S Matthijs, Rittersma Saskia Z H, Pons Douwe, Zwinderman Aeilko H, Doevendans Pieter A F, Tio Rene A, Tijssen Jan G P, Jukema J Wouter, de Winter Robbert J
Abstract excerpt
OBJECTIVE: Restenosis after percutaneous coronary intervention (PCI) remains an issue even in the drug-eluting stent era. Genetic polymorphisms may provide insight in the pathogenesis of restenosis and may help in the stratification of patients at risk for restenosis. The aim of this study was to examine whether polymorphisms at the toll-like receptor 4 (TLR4) locus, that are associated with impaired innate...
Topics
- Angioplasty, Balloon, Coronary
- Coronary Angiography
- Coronary Restenosis
- Female
- Follow-Up Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged