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Article

Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence.

Psychopharmacology - 1 Jan 2004

Pierucci-Lagha Amira, Feinn Richard, Modesto-Lowe Vania, Swift Robert, Nellissery Maggie, Covault Jonathan, Kranzler Henry R

Abstract excerpt

RATIONALE: Rapid tryptophan depletion (RTD) has been used to study central serotonin function and may therefore be useful in understanding co-morbid alcohol dependence (AD) and major depressive disorder (MDD). OBJECTIVES: To examine (1) the effect of RTD on mood and urge to drink among patients with AD and MDD and (2) the association of RTD effects with alleles of a functional polymorphism in the gene encoding...

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Source

Identifiers

PMID: 13680073
DOI: 10.1007/s00213-003-1588-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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