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Article

Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis.

Gastroenterology - 1 Sept 2006

Karlsen Tom H, Lie Benedicte A, Frey Frøslie Kathrine, Thorsby Erik, Broomé Ulrika, Schrumpf Erik, Boberg Kirsten M

Abstract excerpt

BACKGROUND & AIMS: The steroid and xenobiotic receptor (SXR) is a ligand-dependent transcription factor that mediates protection against bile acid-induced liver injury in cholestatic animal models. Ursodeoxycholic acid and rifampicin are known ligands. We investigated whether functional polymorphisms of the SXR gene influence disease susceptibility or disease progression in patients with primary sclerosing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16952547
DOI: 10.1053/j.gastro.2006.05.057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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