Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.

Journal of immunology research - 1 Jan 2015

Wunsch Ewa, Klak Marta, Wasik Urszula, Milkiewicz Malgorzata, Blatkiewicz Malgorzata, Urasinska Elzbieta, Barbier Olivier, Bielicki Dariusz, Bogdanos Dimitrios P, Elias Elwyn, Milkiewicz Piotr

Abstract excerpt

BACKGROUND/AIM: Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). MATERIALS/METHODS: Western-blot/PCRs for SULT2A1/PXR were performed in PSC (n = 11),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangitis, Sclerosing
Share to Intestine, Small

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis, Biliary

Share to MicroRNAs

Share to Pregnane X Receptor

Share to Receptors, Steroid

Share to Sulfotransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 26504856
DOI: 10.1155/2015/571353
PMCID: PMC4609469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR.PMID 26504856Read ↗

Primary sclerosing cholangitis.Semantic proximity Read ↗

PXR: A Xenobiotic Receptor of Diverse Function Implicated in PharmacogeneticsSemantic proximity Read ↗

Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.Semantic proximity Read ↗

Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis.Semantic proximity Read ↗

Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitisSemantic proximity Read ↗

Pregnane X Receptor as the “Sensor and Effector” in Regulating EpigenomeSemantic proximity Read ↗

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4Semantic proximity Read ↗

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3Semantic proximity Read ↗

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 SuperfamilySemantic proximity Read ↗

MMP-2 is a disease-modifying gene in primary sclerosing cholangitis.Semantic proximity Read ↗

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver DiseasesSemantic proximity Read ↗

GLUCURONIDATION: THE LAST DEFENSIVE LINE AGAINST BILE ACID TOXICITY DURING CHOLESTASIS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.