Article
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
PloS one - 25 Aug 2010
Hov Johannes R, Keitel Verena, Laerdahl Jon K, Spomer Lina, Ellinghaus Eva, ElSharawy Abdou, Melum Espen, Boberg Kirsten M, Manke Thomas, Balschun Tobias, Schramm Christoph, Bergquist Annika, Weismüller Tobias, Gotthardt Daniel, Rust Christian, Henckaerts Liesbet, Onnie Clive M, Weersma Rinse K, Sterneck Martina, Teufel Andreas, Runz Heiko, Stiehl Adolf, Ponsioen Cyriel Y, Wijmenga Cisca, Vatn Morten H, Stokkers Pieter C F, Vermeire Severine, Mathew Christopher G, Lie Benedicte A, Beuers Ulrich, Manns Michael P, Schreiber Stefan, Schrumpf Erik, Häussinger Dieter, Franke Andre, Karlsen Tom H
Abstract excerpt
BACKGROUND: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants. METHODOLOGY/PRINCIPAL FINDINGS:...
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