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Article

Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.

Cancer research - 1 Sept 2006

Tsuruta Hiroshi, Kishimoto Hiroyuki, Sasaki Takehiko, Horie Yasuo, Natsui Miyuki, Shibata Yoshiko, Hamada Koichi, Yajima Nobuyuki, Kawahara Koichi, Sasaki Masato, Tsuchiya Norihiko, Enomoto Katsuhiko, Mak Tak Wah, Nakano Toru, Habuchi Tomonori, Suzuki Akira

Abstract excerpt

PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate an urothelium-specific null mutation of Pten in mice [FabpCrePten(flox/flox) (FPten(flox/flox)) mice]. Histologic examination revealed that all FPten(flox/flox) mice exhibited urothelial hyperplasia in which component cells showed enlarged nuclei and increased cell size. With time, 10% of FPten(flox/flox) mice...

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Source

Identifiers

PMID: 16951148
DOI: 10.1158/0008-5472.CAN-05-4627

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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