Article
The evolution of domain arrangements in proteins and interaction networks.
Cellular and molecular life sciences : CMLS - 1 Feb 2005
Bornberg-Bauer E, Beaussart F, Kummerfeld S K, Teichmann S A, Weiner J
Abstract excerpt
Proteins are composed of domains, which are conserved evolutionary units that often also correspond to functional units and can frequently be detected with reasonable reliability using computational methods. Most proteins consist of two or more domains, giving rise to a variety of combinations of domains. Another level of complexity arises because proteins themselves can form complexes with small molecules,...
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