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Article

Structure, function, and evolution of transient and obligate protein-protein interactions.

Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2005

Mintseris Julian, Weng Zhiping

Abstract excerpt

Recent analyses of high-throughput protein interaction data coupled with large-scale investigations of evolutionary properties of interaction networks have left some unanswered questions. To what extent do protein interactions act as constraints during evolution of the protein sequence? How does the type of interaction, specifically transient or obligate, play into these constraints? Are the mutations in the...

Topics

Amino Acid Substitution
Animals
Binding Sites
Evolution, Molecular
Humans
Models, Genetic
Multiprotein Complexes
Mutation
Protein Binding
Proteins
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16043700
DOI: 10.1073/pnas.0502667102
PMCID: PMC1182425

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