Article
The origins of the evolutionary signal used to predict protein-protein interactions.
BMC evolutionary biology - 6 Dec 2012
Swapna Lakshmipuram S, Srinivasan Narayanaswamy, Robertson David L, Lovell Simon C
Abstract excerpt
BACKGROUND: The correlation of genetic distances between pairs of protein sequence alignments has been used to infer protein-protein interactions. It has been suggested that these correlations are based on the signal of co-evolution between interacting proteins. However, although mutations in different proteins associated with maintaining an interaction clearly occur (particularly in binding interfaces and...
Topics
- Chi-Square Distribution
- Databases, Protein
- Evolution, Molecular
- Genetic Variation
- Genome, Fungal
- Phylogeny
- Protein Binding
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins