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Article

The origins of the evolutionary signal used to predict protein-protein interactions.

BMC evolutionary biology - 6 Dec 2012

Swapna Lakshmipuram S, Srinivasan Narayanaswamy, Robertson David L, Lovell Simon C

Abstract excerpt

BACKGROUND: The correlation of genetic distances between pairs of protein sequence alignments has been used to infer protein-protein interactions. It has been suggested that these correlations are based on the signal of co-evolution between interacting proteins. However, although mutations in different proteins associated with maintaining an interaction clearly occur (particularly in binding interfaces and...

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PMID: 23217198
DOI: 10.1186/1471-2148-12-238
PMCID: PMC3537733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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