Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions.

Abstract excerpt

Co-functional proteins tend to have rates of evolution that covary over time. This correlation between evolutionary rates can be measured over the branches of a phylogenetic tree through methods such as evolutionary rate covariation (ERC), and then used to construct gene networks by the identification of proteins with functional interactions. The cause of this correlation has been hypothesized to result from both...

Topics

• Phylogeny
• Gene Regulatory Networks
• Mutation
• Protein Domains