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Article

Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein.

The Journal of experimental medicine - 15 Sept 1997

Das M P, Nicholson L B, Greer J M, Kuchroo V K

Abstract excerpt

We previously generated a panel of T helper cell 1 (Th1) clones specific for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139-151 (HSLGKWLGHPDKF) that induces experimental autoimmune encephalomyelitis (EAE) upon adoptive transfer. In spite of the differences in their T cell receptor (TCR) gene usage, all these Th1 clones required W144 as the primary and most critical TCR contact residue...

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Identifiers

PMID: 9294141
DOI: 10.1084/jem.186.6.867
PMCID: PMC2199041

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