Article
Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99).
Journal of neuroscience research - 15 Sept 1996
Hemmer B, Vergelli M, Calabresi P, Huang T, McFarland H F, Martin R
Abstract excerpt
Experimental allergic encephalomyelitis (EAE), an animal model resembling multiple sclerosis (MS), is mediated by myelin antigen-specific CD4+ T cells secreting cytokines such as interferon-gamma (IFN-gamma), tumor necrosis factor-beta (TNF-beta), and the proinflammatory cytokine TNF-alpha-all as...
Topics
- Amino Acid Sequence
- Autoantibodies
- Clone Cells
- Cytokines
- Epitopes, T-Lymphocyte
- Humans
- Immunodominant Epitopes
- Lymphocyte Activation
- Molecular Sequence Data
- Multiple Sclerosis
- Myelin Basic Protein
- Peptide Fragments
- Phenotype
- T-Lymphocytes