Article
T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes.
Autoimmunity - 1 Jan 1993
Voskuhl R R, Martin R, Bergman C, Dalal M, Ruddle N H, McFarland H F
Abstract excerpt
Multiple sclerosis (MS) is widely accepted as an autoimmune disease with myelin basic protein (MBP) a candidate autoantigen. In the current report, human T cell lines specific for an immunodominant region of MBP were shown to have a functional phenotype similar to T helper 1 (Th1) inflammatory ce...
Topics
- Adult
- Amino Acid Sequence
- Cell Line
- Female
- Humans
- Interferon-gamma
- Interleukin-4
- Lymphotoxin-alpha
- Male
- Molecular Sequence Data
- Myelin Basic Protein
- Phenotype
- T-Lymphocytes, Helper-Inducer