Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant.

Abstract excerpt

There is clinical need to extend the understanding of epilepsy and to find novel approaches to treat this condition. Bang-sensitive (bs) Drosophila mutants, which exhibit reduced thresholds for seizure, offer an attractive possibility to combine tractable genetics, electrophysiology, and high-throughput screening. However, despite these advantages, the precise electrophysiological aberrations that contribute to...

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• Action Potentials
• Anticonvulsants
• Calcium Channels
• Electroshock
• Epilepsy, Reflex