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Article

Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.

Molecular microbiology - 1 Oct 2006

Holmes Ann R, Tsao Sarah, Ong Soo-Wee, Lamping Erwin, Niimi Kyoko, Monk Brian C, Niimi Masakazu, Kaneko Aki, Holland Barbara R, Schmid Jan, Cannon Richard D

Abstract excerpt

Elevated expression of the plasma membrane drug efflux pump proteins Cdr1p and Cdr2p was shown to accompany decreased azole susceptibility in Candida albicans clinical isolates. DNA sequence analysis revealed extensive allelic heterozygosity, particularly of CDR2. Cdr2p alleles showed different abilities to transport azoles when individually expressed in Saccharomyces cerevisiae. Loss of heterozygosity, however,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16942600
DOI: 10.1111/j.1365-2958.2006.05357.x

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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