Article
Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.
Antimicrobial agents and chemotherapy - 1 Dec 2001
Nakamura K, Niimi M, Niimi K, Holmes A R, Yates J E, Decottignies A, Monk B C, Goffeau A, Cannon R D
Abstract excerpt
Analysis of the transport functions of individual Candida albicans plasma membrane drug efflux pumps is hampered by the multitude of endogenous transporters. We have stably expressed C. albicans Cdr1p, the major pump implicated in multiple-drug-resistance phenotypes, from the genomic PDR5 locus in a Saccharomyces cerevisiae mutant (AD1-8u(-)) from which seven major transporters of the ATP-binding cassette (ABC)...
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