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Article

Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.

Eukaryotic cell - 1 Oct 2007

Coste Alix, Selmecki Anna, Forche Anja, Diogo Dorothée, Bougnoux Marie-Elisabeth, d'Enfert Christophe, Berman Judith, Sanglard Dominique

Abstract excerpt

TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a wild-type TAC1 allele drives high expression of CDR1/2 in response to inducers, we showed previously that TAC1 can be hyperactive by a gain-of-function (GOF) point mutation responsible for constitutive high expression of CDR1/2. High...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Fungal

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Source

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Identifiers

PMID: 17693596
DOI: 10.1128/EC.00151-07
PMCID: PMC2043391

Genes

TAC1
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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