Article
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Human mutation - 1 Oct 2006
Wood Laura D, Calhoun Eric S, Silliman Natalie, Ptak Janine, Szabo Steve, Powell Steve M, Riggins Gregory J, Wang Tian-Li, Yan Hai, Gazdar Adi, Kern Scott E, Pennacchio Len, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E
Abstract excerpt
Tyrosine kinases are major regulators of signal transduction cascades involved in cellular proliferation and have important roles in tumorigenesis. We have recently analyzed the tyrosine kinase gene family for alterations in human colorectal cancers and identified somatic mutations in seven members of this gene family. In this study we have used high-throughput sequencing approaches to further evaluate this...
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