Article
Somatic mutations in human cancer: insights from resequencing the protein kinase gene family.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Futreal P A, Wooster R, Stratton M R
Abstract excerpt
All cancers arise due to the accumulation of mutations in critical target genes that, when altered, give rise to selective advantage in the cell and its progeny that harbor them. Knowledge of these mutations is key in understanding the biology of cancer initiation and progression, as well as the development of more targeted therapeutic strategies. We have undertaken a systematic screen of all annotated protein...
Topics
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Female
- Humans
- Lung Neoplasms
- Male
- Mutation
- Neoplasms
- Protein Kinases
- Testicular Neoplasms