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Article

Molecular mechanism of a thumb domain hepatitis C virus nonnucleoside RNA-dependent RNA polymerase inhibitor.

Antimicrobial agents and chemotherapy - 1 Dec 2006

Howe Anita Y M, Cheng Huiming, Thompson Ian, Chunduru Srinivas K, Herrmann Steve, O'Connell John, Agarwal Atul, Chopra Rajiv, Del Vecchio Alfred M

Abstract excerpt

A new pyranoindole class of small-molecule inhibitors was studied to understand viral resistance and elucidate the mechanism of inhibition in hepatitis C virus (HCV) replication. HCV replicon variants less susceptible to inhibition by the pyranoindoles were selected in Huh-7 hepatoma cells. Variant replicons contained clusters of mutations in the NS5B polymerase gene corresponding to the drug-binding pocket on...

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Identifiers

PMID: 16940072
DOI: 10.1128/AAC.00365-06
PMCID: PMC1693979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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