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Article

In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

Antimicrobial agents and chemotherapy - 1 Feb 2008

Shi Stephanie T, Herlihy Koleen J, Graham Joanne P, Fuhrman Shella A, Doan Chau, Parge Hans, Hickey Michael, Gao Jingjin, Yu Xiu, Chau Fannie, Gonzalez Javier, Li Hui, Lewis Cristina, Patick Amy K, Duggal Rohit

Abstract excerpt

A novel class of nonnucleoside hepatitis C virus (HCV) polymerase inhibitors characterized by a dihydropyrone core was identified by high-throughput screening. Crystallographic studies of these compounds in complex with the polymerase identified an allosteric binding site close to the junction of the thumb and finger domains, approximately 30 A away from the catalytic center. AG-021541, a representative compound...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18070954
DOI: 10.1128/AAC.00834-07
PMCID: PMC2224781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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