Article
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.
Bioorganic & medicinal chemistry letters - 1 Jun 2012
Liu Yaya, Lim Ben Hock, Jiang Wen W, Flentge Charles A, Hutchinson Douglas K, Madigan Darold L, Randolph John T, Wagner Rolf, Maring Clarence J, Kati Warren M, Molla Akhteruzzaman
Abstract excerpt
Aryl dihydrouracil derivatives were identified from high throughput screening as potent inhibitors of HCV NS5B polymerase. The aryl dihydrouracil derivatives were shown to be non-competitive with respect to template RNA and elongation nucleotide substrates. They demonstrated genotype 1 specific activity towards HCV NS5B polymerases. Structure activity relationships and genotype specific activities of aryl...
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