Article
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Antimicrobial agents and chemotherapy - 1 Sept 2008
Howe Anita Y M, Cheng Huiming, Johann Stephen, Mullen Stanley, Chunduru Srinivas K, Young Dorothy C, Bard Joel, Chopra Rajiv, Krishnamurthy Girija, Mansour Tarek, O'Connell John
Abstract excerpt
HCV-796 selectively inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In hepatoma cells containing a genotype 1b HCV replicon, HCV-796 reduced HCV RNA levels by 3 to 4 log(10) HCV copies/mug total RNA (the concentration of the compound that inhibited 50% of the HCV RNA level was 9 nM). Cells bearing replicon variants with reduced susceptibility to HCV-796 were generated in the presence of...
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