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Article

Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.

Journal of virology - 1 Jun 2006

Le Pogam Sophie, Kang Hyunsoon, Harris Seth F, Leveque Vincent, Giannetti Anthony M, Ali Samir, Jiang Wen-Rong, Rajyaguru Sonal, Tavares Gisele, Oshiro Connie, Hendricks Than, Klumpp Klaus, Symons Julian, Browner Michelle F, Cammack Nick, Nájera Isabel

Abstract excerpt

Multiple nonnucleoside inhibitor binding sites have been identified within the hepatitis C virus (HCV) polymerase, including in the palm and thumb domains. After a single treatment with a thumb site inhibitor (thiophene-2-carboxylic acid NNI-1), resistant HCV replicon variants emerged that contained mutations at residues Leu419, Met423, and Ile482 in the polymerase thumb domain. Binding studies using wild-type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16731953
DOI: 10.1128/JVI.02628-05
PMCID: PMC1472602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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