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Article

1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.

Antimicrobial agents and chemotherapy - 1 Dec 2008

Nyanguile Origène, Pauwels Frederik, Van den Broeck Walter, Boutton Carlo W, Quirynen Ludo, Ivens Tania, van der Helm Liesbet, Vandercruyssen Geneviève, Mostmans Wendy, Delouvroy Frédéric, Dehertogh Pascale, Cummings Maxwell D, Bonfanti Jean-Francois, Simmen Kenneth A, Raboisson Pierre

Abstract excerpt

The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we report the discovery of a novel class of HCV po...

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Identifiers

PMID: 18852280
DOI: 10.1128/AAC.00669-08
PMCID: PMC2592889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18852280-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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