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Article

A <i>Drosophila</i> model of the rhabdomyosarcoma initiator PAX7-FKHR

28 Aug 2006

Abstract excerpt

Alveolar rhabdomyosarcoma (ARMS) is an aggressive myogenic-type tumor and a gain-of-function disease, caused by misexpression of the PAX3-FKHR or PAX7-FKHR fusion oncoprotein from structurally rearranged chromosomes. PAX3-FKHR misexpressed in terminally differentiating mouse myofibers can cause rhabdomyosarcoma at a low frequency, suggesting that skeletal muscle is an ARMS tissue of origin. Because patterned...

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PMID: 16938866
DOI: 10.1073/pnas.0605926103

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