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Article

Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?

Cancer letters - 8 Jul 2009

Charytonowicz Elizabeth, Cordon-Cardo Carlos, Matushansky Igor, Ziman Mel

Abstract excerpt

Alveolar rhabdomyosarcoma (ARMS) is a pediatric sarcoma that typically occurs in older children predominantly arising in the trunk and extremities, and exhibits a worse prognosis than other types of rhabdomyosarcomas. Most ARMS tumors have t(2; 13) or t(1; 13) translocations, involving PAX3-FKHR and PAX7-FKHR fusion genes, respectively. These genetic events result in a molecular gain of function of the fusion...

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Topics

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Share to Cell Differentiation
Share to Cell Transformation, Neoplastic
Share to Mesenchymal Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Neoplastic Stem Cells

Share to Oncogene Proteins, Fusion

Share to Paired Box Transcription Factors

Share to Translocation, Genetic

Source

Identifiers

PMID: 19008039
DOI: 10.1016/j.canlet.2008.09.039

Genes

PAX3
PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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