Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

Genes & development - 1 Nov 2004

Keller Charles, Arenkiel Benjamin R, Coffin Cheryl M, El-Bardeesy Nabeel, DePinho Ronald A, Capecchi Mario R

Abstract excerpt

Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has yet been reported. We report the first mouse model of alveolar rhabdomyosarcoma using a conditional Pax3:Fkhr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Genetic Engineering

Share to Myogenic Regulatory Factors

Share to Paired Box Transcription Factors

Share to PAX3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 15489287
DOI: 10.1101/gad.1244004
PMCID: PMC525542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.PMID 15489287Read ↗

New Genetic Tactics to Model Alveolar Rhabdomyosarcoma in the MouseSemantic proximity Read ↗

Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.Semantic proximity Read ↗

Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations.Semantic proximity Read ↗

Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.Semantic proximity Read ↗

Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?Semantic proximity Read ↗

Defining the Cooperative Genetic Changes That Temporally Drive Alveolar RhabdomyosarcomaSemantic proximity Read ↗

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitorsSemantic proximity Read ↗

The <i>PAX3-FKHR</i> Fusion Gene of Rhabdomyosarcoma Cooperates with Loss of p16INK4A to Promote Bypass of Cellular SenescenceSemantic proximity Read ↗

A <i>Drosophila</i> model of the rhabdomyosarcoma initiator PAX7-FKHRSemantic proximity Read ↗

The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomysarcoma.Semantic proximity Read ↗

PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.Semantic proximity Read ↗

Fusions Involving PAX and FOX Genes in the Molecular Pathogenesis of Alveolar Rhabdomyosarcoma: Recent AdvancesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.