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Article

Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.

Biochemical and biophysical research communications - 18 Jan 2008

Kikuchi Ken, Tsuchiya Kunihiko, Otabe Osamu, Gotoh Takahiro, Tamura Shinichi, Katsumi Yoshiki, Yagyu Shigeki, Tsubai-Shimizu Satoko, Miyachi Mitsuru, Iehara Tomoko, Hosoi Hajime

Abstract excerpt

The malignancy of alveolar rhabdomyosarcoma (ARMS) has been linked to expression of the PAX3-FKHR chimeric gene. To understand the effect of this gene, we used RNAi to knock down its expression (without affecting the expressions of either PAX3 or FKHR) in human ARMS cell lines. Down-regulating PA...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PAX3 gene

Share to Muscle Development

Share to Oncogene Proteins, Fusion

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Share to RNA, Small Interfering

Source

Identifiers

PMID: 18022385
DOI: 10.1016/j.bbrc.2007.11.017

Genes

PAX3
HGF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18022385-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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