Article

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applications

2021-06-15

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of about 65-70%. Thus, additional molecular insights and representative models are critical for further identifying and evaluating new treatment modalities. Using MyoD-Cre mediated introduction of mutant K-Ras G12D and perturbations in p53 we have developed a novel genetically engineered mouse model (G...

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Literature Corpus work: c1c858a0-60a5-500e-b310-508161aebff3
DOI: 10.1101/2021.06.15.448607

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MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applicationsDOI 10.1101/2021.06.15.448607Read

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