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Article

Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations.

Cancer research - 15 Aug 2008

Ren Yue-Xin, Finckenstein Friedrich Graf, Abdueva Diana A, Shahbazian Violette, Chung Brile, Weinberg Kenneth I, Triche Timothy J, Shimada Hiroyuki, Anderson Michael J

Abstract excerpt

Alveolar rhabdomyosarcomas (ARMS) are highly malignant soft-tissue sarcomas that arise in children, adolescents, and young adults. Although formation and expression of the PAX-FKHR fusion genes is thought to be the initiating event in this cancer, the role of PAX-FKHR in the neoplastic process remains largely unknown in a progenitor cell that is undefined. We hypothesize that PAX-FKHR determine the ARMS...

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PMID: 18701482
DOI: 10.1158/0008-5472.CAN-08-0859

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MSC

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