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Article

A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain.

Nature structural & molecular biology - 1 Sept 2006

Rideau Alexis P, Gooding Clare, Simpson Peter J, Monie Tom P, Lorenz Mike, Hüttelmaier Stefan, Singer Robert H, Matthews Stephen, Curry Stephen, Smith Christopher W J

Abstract excerpt

Polypyrimidine tract-binding protein (PTB) is a regulatory splicing repressor. Raver1 acts as a PTB corepressor for splicing of alpha-tropomyosin (Tpm1) exon 3. Here we define a minimal region of Raver1 that acts as a repressor domain when recruited to RNA. A conserved [S/G][I/L]LGxxP motif is es...

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PMID: 16936729
DOI: 10.1038/nsmb1137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16936729-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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