Article
Structural basis of UCUU RNA motif recognition by splicing factor RBM20.
Nucleic acids research - 7 May 2020
Upadhyay Santosh Kumar, Mackereth Cameron D
Abstract excerpt
The vertebrate splicing factor RBM20 (RNA binding motif protein 20) regulates protein isoforms important for heart development and function, with mutations in the gene linked to cardiomyopathy. Previous studies have identified the four nucleotide RNA motif UCUU as a common element in pre-mRNA targeted by RBM20. Here, we have determined the structure of the RNA Recognition Motif (RRM) domain from mouse RBM20 bound...
Topics
- Animals
- Cardiomyopathies
- Mice
- Models, Molecular
- Mutation
- Nucleotide Motifs
- Polypyrimidine Tract-Binding Protein
- Protein Binding
- Protein Structure, Secondary
- RNA
- RNA Recognition Motif
- RNA-Binding Proteins
- Uracil