Article
Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017
Zhang Heng, Liu Ke, Izumi Natsuko, Huang Haiming, Ding Deqiang, Ni Zuyao, Sidhu Sachdev S, Chen Chen, Tomari Yukihide, Min Jinrong
Abstract excerpt
The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway plays a central role in transposon silencing and genome protection in the animal germline. A family of Tudor domain proteins regulates the piRNA pathway through direct Tudor domain-PIWI interactions. Tudor domains are known to fulfill this function by binding to methylated PIWI proteins in an arginine methylation-dependent manner. Here, we...
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