Article
Prion protein 90-231 contains a streptavidin-binding motif.
Biochemical and biophysical research communications - 13 Oct 2006
Boetel Thurid, Bade Steffen, Schmidt Marcus Alexander, Frey Andreas
Abstract excerpt
The biological function of prion protein (PrP) and the physiological relevance of its truncated subtypes and glycoforms is still enigmatic. In this paper, we adduce evidence that recombinant murine PrP fragment 90-231 (mPrP90-231) contains a biotin-mimicking sequence motif that causes binding of the bacterial protein streptavidin to mPrP90-231. As indicated by epitope mapping and proven by analysis of a deletion...
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