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Article

Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrP Sc

6 Jul 2004

Abstract excerpt

Prion diseases are closely associated with the conversion of the cellular prion protein (PrPC) to an abnormal conformer (PrPSc) [Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. USA 95, 13363-13383]. Monoclonal antibodies that bind epitopes comprising residues 96-104 and 133-158 of PrPC potently inhibit this process, presumably by preventing heterodimeric association of PrPC and PrPSc, and suggest that these regions...

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PMID: 15240877
DOI: 10.1073/pnas.0403522101

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