Article
Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.
Molecular biology of the cell - 1 Dec 2010
Emerman Amy B, Zhang Zai-Rong, Chakrabarti Oishee, Hegde Ramanujan S
Abstract excerpt
Proteins are often made in more than one form, with alternate versions sometimes residing in different cellular compartments than the primary species. The mammalian prion protein (PrP), a cell surface GPI-anchored protein, is a particularly noteworthy example for which minor cytosolic and transmembrane forms have been implicated in disease pathogenesis. To study these minor species, we used a selective labeling...
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