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Article

Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation.

Thrombosis and haemostasis - 1 Mar 2004

Epple Guido, Langfeld Kristina, Baier Michael, Holzhütter Hermann-Georg, Schleuning Wolf-Dieter, Köttgen Eckart, Gessner Reinhard, Praus Michael

Abstract excerpt

We have recently shown that the NH(2)-terminal fragment (PrP23-110) of the human cellular prion protein (PrP(c) ) stimulates t-PA mediated plasminogen activation. PrP23-110 contains an N-terminal lysine cluster (LC1; K(23),K(24), K(27)) and a C-terminal one (LC2; K(101),K(104),K(106),K(110)). To study their biological function we have substituted all lysine residues of each cluster by alanine and generated the...

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PMID: 14983221
DOI: 10.1160/TH03-06-0382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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